Cisplatin feeder cell
WebThe regimen of irinotecan and cisplatin consisted of four four-week cycles of 60 mg of irinotecan per square meter of body-surface area on days 1, 8, and 15 and 60 mg of cisplatin per square... WebCisplatin is a major anticancer drug that kills cancer cells by damaging their DNA. Cancer cells cope with the drug by removal of the damages with nucleotide excision repair. We have developed methods to measure cisplatin adduct formation and its repair at single-nucleotide resolution.
Cisplatin feeder cell
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WebFeb 11, 2024 · In this study, a cisplatin resistant gastric cancer cell line SGC7901R was determined by LC-MS/MS with increased exosomal levels of RPS3 protein. SGC7901R … WebCisplatin (50 microM) produced time-dependent apo … The chemotherapeutic cisplatin causes renal dysfunction and renal proximal tubular cell (RPTC) apoptosis. The goal of these studies was to examine the role of p53, caspase 3, 8, and 9, and mitochondria in the signaling of cisplatin-induced apoptosis.
WebDec 7, 2024 · In this study, we compared the efficacy and safety between the cisplatin plus etoposide (EP) and carboplatin plus etoposide (EC) regimens. Methods A total of 1305 patients with previously untreated ES-SCLC were included in this study. Data from five trials were collected from the public database Project Data Sphere. WebIrinotecan plus cisplatin is an effective treatment for metastatic small-cell lung cancer. The usual chemotherapy for extensive small-cell lung cancer is etoposide plus cisplatin or …
WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. … WebCisplatin is a type of chemotherapy. It destroys quickly dividing cells, such as cancer cells. Find out more about how chemotherapy works How do you have cisplatin? You have …
WebAug 1, 2015 · Feeder cells produce a number of growth factors and cytokines that could eventually be replaced by added recombinant proteins to the culture medium. (b) Juxtacrine and physical interactions. The presence of feeder cells is mandatory for target cells to grow, since cell–cell contact mediate juxtacrine signaling pathways and/or mechanical …
WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, … candice swanepoel in blackWebCisplatin can also be transported out of the cell, and this constitutes the next potential mechanism of resistance. Two key players in cisplatin efflux are the aforementioned … fish pcosWebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, … candice swanepoel hipsWebOct 22, 2024 · Cisplatin is an alkylating agent which induces DNA damage through the formation of cisplatin-DNA adducts, leading to cell cycle arrest and apoptosis. In the … fish pc backgroundWebCisplatin is administered through a vein (intravenously or IV) as an infusion. There is no pill form of cisplatin. Cisplatin is an irritant. An irritant is a chemical that can cause … candice swanepoel in shortsWebMay 22, 2024 · Although almost all cisplatin-resistant HNSCC cells we tested showed higher ETS-1 phosphorylation levels at T38, we found that inhibition of MEK/ERK pathways with the MEK inhibitor PD0325901 did not block this phosphorylation. fish pclWebTwo major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity. One possible mechanism by which resistance is reported to develop is a reduction in … candice swanepoel kia