Phosphopantetheine binding acp domain

Author: mssi

August undefined, 2024

WebMar 2, 2010 · 7 malonyl-CoA + hexanoyl- [acyl-carrier protein] = 7 CoA + norsolorinate anthrone + [acyl-carrier protein] + 7 CO (2) + 2 H (2)O. Biochemical function: not assigned. … WebFeb 20, 2024 · Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to …

The Crystal Structure of a Mammalian Fatty Acid Synthase

WebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ( [ACP]) domain. Catalytic activity acetyl-CoA + 2n H+ + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP+ 3 publications WebNov 20, 2024 · Fatty acid and phospholipid metabolism Other PAO1 genes in this class Pathways Functional Predictions from Interpro Search for additional functional domains at the NCBI CDD database website. Go to this protein's … open water marathon

protein coding gene - lys1 (SPAP7G5.04c) - PomBase

WebPhosphopantetheine transferases (PPTases) from E. coli (AcpS) and Bacillus subtilis (Sfp) have been used for the enzyme-mediated protein labeling system ( Fig. 5A ). 143 PPTases catalytically transfer 4′-phosphopantetheine from coenzyme A (CoA) to the serine residue of an acyl carrier protein (ACP) or peptidyl carrier protein (PCP). WebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. 2 publications Catalytic activity WebJul 31, 2014 · (1) Movement of the ACP’s phosphopantetheine (Ppant) arm is thought to be coordinated with protein–protein interactions and significant rearrangement of the PKS enzyme assembly. (2-5) The dynamic structures of ACPs and their Ppant arms are difficult to track due to the flexibility of ACPs and ACPs’ transient interactions with catalytic … ipec static screen

Phosphopantetheine-binding site.: (A) Structural superposition of ...

WebAcyl carrier protein (ACP) is a universal and highly conserved carrier of acyl intermediates during fatty acid synthesis. In yeast and mammals, ACP exists as a separate domain within a large multifunctional fatty acid synthase polyprotein (type I FAS), whereas it is a small monomeric protein in bacteria and plastids (type II FAS). Webthe S. cerevisiae FAS (19, 20), the missing ACP domain was subsequently located, docked to the KS domain. We have recently purified the S. cerevisiae fatty acid synthase ... third part binding the CoA or ACP phosphopantetheine group that transfers the acyl and malonyl substrates. In the large fungal fatty acid complex, the KS dimers were ... open water lyrics king gizzardWebPhosphopantetheine-binding site.: (A) Structural superposition of ATP-bound MsFadD32 and adenylate analog- and phosphopantetheine-bound PA1221 protein. The N- and C … open water propeller curve

"WebFeb 20, 2024 · Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to present acyl substrates to a... " - Phosphopantetheine binding acp domain

Phosphopantetheine binding acp domain

ZFIN Gene: ndufab1a - Zebrafish Information Network

WebJul 22, 2015 · Acyl carrier protein (ACP) Phosphopantetheine binding ACP domain; Structure analysis Details. Assembly composition: monomeric . Entry contents: 1 distinct polypeptide molecule ... Sequence domains: Phosphopantetheine attachment site. Ligands and Environments No bound ligands. No modified residues. WebJun 2, 2011 · Introduction. One of the most distinctive features of fatty acid, nonribosomal peptide and polyketide biosynthetic pathways is the utilization of the acyl carrier protein (ACP) or peptidyl carrier protein (PCP) for the shuttling of biosynthetic intermediates among various catalytic domains or proteins –.The small and highly dynamic ACPs or PCPs can …

Did you know?

WebJan 12, 2024 · Phosphopantetheine binding ACP domain (Q24722578) InterPro Domain PP-bd_ACP IPR009081 edit Statements instance of protein domain 1 reference subclass of … WebPhosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). [1]

WebSep 5, 2008 · FAS inhibitors have demonstrated anti-tumor activity in vivo and in vitro, and in recent years FAS has emerged as an important drug target for the treatment of human … The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. In both cases, the growing chain is bound to the ACP via a thioester derived from the distal thiol of a 4'-phosphopantetheine moiety.

WebApr 20, 2024 · ACP-like superfamily, phosphopantetheine binding ACP domain, trimeric LpxA–like superfamily, AMP-dependent synthetase–like superfamily, polyketide synthase, phosphopantetheine-binding domain, AMP-dependent synthetase/ligase: −1.20: −2.32: −1.12: 0.117796: 0.537084: g11299: WebNov 20, 2024 · Phosphopantetheine binding ACP domain; Chloramphenicol acetyltransferase-like domain superfamily; 3 more domains. Structure analysis Details. Assembly composition: monomeric . Entry contents: 1 distinct polypeptide molecule. Macromolecule: Linear gramicidin synthase subunit A Chains: A, B. Molecule details › ...

WebFeb 17, 2016 · This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. automatic annotation. Catalytic activity (2E) ... …

Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. open water layout boatWebChr: 1 Mapping Details/Browsers Description Predicted to enable acyl binding activity and acyl carrier activity. Predicted to act upstream of or within fatty acid biosynthetic process. … open water swim canary wharfWebPhosphopantetheine-binding. Status. UniProtKB unreviewed (TrEMBL) ... Family and domain databases. Gene3D. ... IPR036736 ACP-like_sf; IPR020806 PKS_PP-bd; IPR009081 PP … ipecs uce+WebFeb 16, 2016 · The selection of the starter unit is generally governed by the substrate specificity of the AT domain in the loading module ().In some modular PKS systems, a didomain-type loading module comprising a loading AT domain and an ACP domain selects an acyl starter building block such as an acetate unit to generate an acyl–ACP … open water swim camps 2022WebIts crystal structure contains five catalytic domains, two nonenzymatic domains and a shuttle protein domain. Overexpression in FAS can be linked to development of cancer cells (1). Activity of fatty acid synthase (FAS) in mammals is often low in most body tissue. ipecs telephone manualWebApr 10, 2024 · HIGHLIGHTS. who: Filamentous Fungi and collaborators from the National Cheng Kung University, Taiwan have published the research work: Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi, in the Journal: (JOURNAL) how: This Tet-On system was applied with A. fumigatus for inducible expression of the gene of … ipec stockportWebView Lecture_set+5+lipid+synthesis+notes.pdf from CHEM 153C at UCLA Community School-Los Angeles. The input to fatty acid synthesis is acetyl-CoA, which is carboxylated to malonyl-CoA. The open water real story